DBT-NIBMG creates world’s 1st database of Oral Cancer variants

WHY IN NEWS?

Department of Biotechnology (DBT) & National Institute of Biomedical Genomics (NIBMG) has created a first of its king database of genomic variation in oral cancer. NIBMG made this database accessible to public. Database is being called as dbGENVOC.

About dbGENVOC

• It is a free resource and a browsable online database of genomic Variants of Oral Cancer. First release of dbGENVOC comprises of

1. 24 million somatic and germline variants which have been derived from whole exome sequences of 100 oral cancer patients & whole genome sequences of 5 oral cancer patients.
2. Somatic variation data from 220 patient samples were collected from USA and analyzed by TCGA-HNSCC project.
3. Variants were identified by community approved best practice protocol and were annotated with the help of multiple analytic pipelines.

• dbGENVOC is a catalogue of genomic variants as well as a built-in search engine. It allows a reasonable extent of statistical and bioinformatic analysis to be carried out such as identification of variants in associated altered pathways in oral cancer.
• It will be updated annually with variation data of new oral cancer patients from India southeast Asia.
• It will support advances in oral cancer research.