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| Disease | Impact | Drop in cost |
| Tyrosinemia type 1 | used to require an annual expenditure of ₹ 2.2 crore to ₹ 6.5 crore, now costs ₹ 2.5 lakh for the same duration.
If untreated, a child dies of the disease by the age of 10. The drug for treating the disease is called Nitisinone. |
|
| Gaucher’s Disease | results in liver or spleen enlargement, bone pain and fatigue | Eliglustat capsules- cost brought down from ₹ 1.8-3.6 crore per year to ₹ 3.6 lakh |
| Wilson’s Disease | causes a copper deposit in the liver and psychiatric symptoms | Trientine capsules- from ₹ 2.2 crore to ₹ 2.2 lakh per year |
| Dravet/ Lennox Gastaut Syndrome | causes complex seizure syndromes | Cannabidiol oral solution, from ₹ 7-34 lakh per year to ₹ 1-5 lakh. |
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ABOUT DELIMITATION COMMISSION
| 42nd Constitutional Amendment (1976) froze this delimitation exercise until the first Census after 2000 was published.
In 2002, the 84th Constitutional Amendment further extended the freeze till 2026. |
 I R COELHO V. STATE OF TAMIL NADU (2007) JUDGEMENT
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